2020年秋学期 - 分子栄養学と健康 / MOLECULAR NUTRITIONAL SCIENCE FOR HEALTH

C2044
分子栄養学と健康
MOLECULAR NUTRITIONAL SCIENCE FOR HEALTH

特設科目
Special Seminars
2 単位

実施形態	完全オンライン
開催日程	秋学期火曜日３時限
担当教員	渡辺光博（ワタナベミツヒロ）
関連科目	前提科目（推奨）: B6154,90606,X1013,B6153,90547,90536 前提科目（関連）: B6154,90606,X1013,B6153,90547,90536
開講場所	SFC
授業形態	講義、実習・演習、グループワーク
履修者制限	履修人数を制限する受入学生数（予定）：約 25 人選抜方法：課題提出による選抜【課題内容】 Test will be given about the following papers before the first time (session). Students are required to read and understand send report in advance.　　　　　 Please make a report about the following issue.　　　　　 Q1, About relations of bile acid and the metabolism. Q2, How does LXR affect fatty liver and insulin resistance? Q3, About relations of the metabolism of sugar and lipid and the amino acid at the time of fast.　　　　　 Ref.　　　　　　 1, Watanabe M(Corresponding Author), Morimoto M, Houten S, Kaneko-Iwasaki N, Sugizaki T, Horai Y, Mataki C, Sato H, Murahashi K, Arita E, Schoonjans K, Suzuki T, Itoh H and Auwerx J. Bile acid binding resin improves metabolic control through the induction of energy expenditure. PLoS ONE. 2012; 7(8): e38285.　　　　　 2, Sugizaki T, Watanabe M, Horai Y, Kaneko-Iwasaki N, Arita E, Miyazaki T, Morimoto K, Honda A, Irie J, Itoh H.　 The Niemann-Pick C1 Like 1 (NPC1L1) inhibitor Ezetimibe improves metabolic disease via decreased Liver X Receptor (LXR) activity in liver of obese male mice.　Endocrinology. 2014 Apr 28:en20132143.　　　　　 3, Watanabe M (Corresponding Author), Horai Y, Houten SM, Morimoto K, Sugizaki T, Arita E, Mataki C, Sato H, Tanigawara Y, Schoonjans K, Itoh H and Auwerx J. Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure. J Biol Chem. 2011; 286: 26913-26920.　　　　　 4, Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006; 439: 484-489.　　　　　 5, Harach T, Pols TW, Nomura M, Maida A, Watanabe M, Auwerx J, Schoonjans K. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.Nature. Sci Rep. 2012;　2: 430.　　　　　 ◯エントリー〆切日時：2020年9月28日（月） 17:00 ◯履修許可者発表日時：2020年9月30日（水） 17:00 ◯テキスト入力 Only the selected students can take this course. Number of students in the class (scheduled) : About 25 Pre-registration screening by submitted an assignment 【ASSIGNMENT】 Test will be given about the following papers before the first time (session). Students are required to read and understand send report in advance.　　　　　 Please make a report about the following issue.　　　　　 Q1, About relations of bile acid and the metabolism. Q2, How does LXR affect fatty liver and insulin resistance? Q3, About relations of the metabolism of sugar and lipid and the amino acid at the time of fast.　　　　　 Ref.　　　　　　 1, Watanabe M(Corresponding Author), Morimoto M, Houten S, Kaneko-Iwasaki N, Sugizaki T, Horai Y, Mataki C, Sato H, Murahashi K, Arita E, Schoonjans K, Suzuki T, Itoh H and Auwerx J. Bile acid binding resin improves metabolic control through the induction of energy expenditure. PLoS ONE. 2012; 7(8): e38285.　　　　　 2, Sugizaki T, Watanabe M, Horai Y, Kaneko-Iwasaki N, Arita E, Miyazaki T, Morimoto K, Honda A, Irie J, Itoh H.　 The Niemann-Pick C1 Like 1 (NPC1L1) inhibitor Ezetimibe improves metabolic disease via decreased Liver X Receptor (LXR) activity in liver of obese male mice.　Endocrinology. 2014 Apr 28:en20132143.　　　　　 3, Watanabe M (Corresponding Author), Horai Y, Houten SM, Morimoto K, Sugizaki T, Arita E, Mataki C, Sato H, Tanigawara Y, Schoonjans K, Itoh H and Auwerx J. Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure. J Biol Chem. 2011; 286: 26913-26920.　　　　　 4, Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006; 439: 484-489.　　　　　 5, Harach T, Pols TW, Nomura M, Maida A, Watanabe M, Auwerx J, Schoonjans K. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.Nature. Sci Rep. 2012;　2: 430.　　　　　 * Schedule: TBD
履修条件
使用言語	英語
連絡先	wmitsu@sfc.keio.ac.jp
授業ホームページ
同一科目
学生が利用する予定機材/ソフト等
設置学部・研究科	総合政策・環境情報学部
大学院プロジェクト名
大学院プロジェクトサブメンバー
ゲストスピーカーの人数	0
履修選抜・課題タイプ=テキスト登録可	true
履修選抜・選抜課題タイプ=ファイル登録可	false
GIGAサティフィケート対象	true
最終更新日	2020/07/22 13:15:07

科目概要

　The world’s nations face rapid aging, and in Japan’s unprecedented super aging society, 30% of the population will be 65 or older by 2030, rising to 40% by 2055. The world’s eyes are upon Japan to see how we handle this situation. Publicly-financed medical care costs exceed 33 trillion yen, and are climbing by one trillion yen annually. I believe that this severe crisis presents itself, on the contrary, as an opportunity to share our accumulated know-how with the global nations in similar straits. The average human lifespan in Japan is 80.9 years, 74.5 of them lived in reasonable health, leaving 6.4 years spent in a bedridden or similar state. Approximately 66% of lifelong medical expenses occur after age 60, with about half remaining after age 70, and some 20% occurring during the final year of life. However, recent research suggests that medical care costs do not expand with a longer life; in fact, healthy longevity sees across-the-board decreases in medical care costs. In other words, achieving healthy longevity not only results in a better QOL (quality of life) for the vital individual and family, but also positively impacts rising publicly-financed medical care costs.

世界中の国々が急速に高齢化に向かっているが、日本における超高齢化社会は世界に例を見ないスピードで進行しており、６５歳以上の人口が２０３０年には３０％、２０５５年には４０％を超えると推定されており、我が国がどのように対処していくか、世界中が注目している状況である。３３兆円を超える国の医療財政は毎年１兆円の伸びを示し、大変厳しい状況であるが、この危機的状況は逆にチャンスであり、今後、世界の多くの国が直面する同様の状況にそのノウハウを提供することができると考える。人の平均的な一生は寿命が８０，９歳、健康寿命が７４，５歳で死亡前の６，４年は寝たきりなどの状態になる。また、生涯医療費の約６６％は６０歳以降、約５０％は７０歳以降に、そして死亡１年前の終末期医療費は約２０％を消費される。しかしながら、最近の研究では長寿で医療費は増加せず、むしろ健康長寿では大幅に軽減されることが分かっている。つまり健康長寿が実現されればピンピンコロリで本人や家族のＱＯＬが向上するばかりでなく増加する医療財政にも好影響を与えることになる。

授業シラバス

主題と目標／授業の手法など

教材・参考文献

I’ll show you teaching materials during session.

提出課題・試験・成績評価の方法など

Individual evaluation will make a comprehensive judgment by attendance, In-class presentations, and class participation.

履修上の注意

授業計画

第1回 Guidance

Explain how to lead the class.

第2回 ntroduction to metabolism 1

Lecture of the metabolism outline

第3回 ntroduction to metabolism 2

Lecture of the metabolism outline

第4回 Introduction to metabolism 3

Lecture of the metabolism outline

第5回 Presentation about research 1