2020年秋学期 - 細胞レベルの生命科学による革新 / THE EPOCH-MAKING DISCOVERIES IN CELL BIOLOGY
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C2045 細胞レベルの生命科学による革新 THE EPOCH-MAKING DISCOVERIES IN CELL BIOLOGY |
特設科目 Special Seminars 2 単位 |
| 実施形態 | 完全オンライン |
| 開催日程 | 秋学期 火曜日４時限 |
| 担当教員 | 黒田 裕樹（クロダ ヒロキ） |
| 関連科目 |
前提科目（関連）: 90544,95019,34190,34180,34170,34160 |
| 開講場所 | SFC |
| 授業形態 | 講義 |
| 履修者制限 |
履修人数を制限する Only the selected students can take this course. |
| 履修条件 |
特に無し N/A |
| 使用言語 | 英語 |
| 連絡先 | hkuroda@sfc.keio.ac.jp |
| 授業ホームページ | |
| 同一科目 | |
| 学生が利用する予定機材/ソフト等 | |
| 設置学部・研究科 | 総合政策・環境情報学部 |
| 大学院プロジェクト名 | |
| 大学院プロジェクトサブメンバー | |
| ゲストスピーカーの人数 | 0 |
| 履修選抜・課題タイプ=テキスト登録可 | false |
| 履修選抜・選抜課題タイプ=ファイル登録可 | false |
| GIGAサティフィケート対象 | true |
| 最終更新日 | 2020/08/26 14:54:20 |
科目概要
Approximately three-fourths of the Nobel prize in Physiology or Medicine and half of the Nobel prize in Chemistry have been related to Life Science-Cell Biology. There has been no such academic domain. I think that the reason why Cell Biology is so special is because it has been worked as a driving force to support human society and health. In this class, I am planing to explain some extremely important and epoch making discoveries from the recent 30-years Nobel prize (especially, if it is performed by Japanese scientists).
授業シラバス
主題と目標／授業の手法など
It should be useful for your creative life in future to know the reason why the Nobel prize has been given for some studies in Cell Biology.
Basically, no special knowledge are not required for it. This class is translated version (originally prepared as Japanese version).
教材・参考文献
休み時間の分子生物学
提出課題・試験・成績評価の方法など
Results are judged by the number of times of your attendance, and your score of reports.
履修上の注意
授業計画
第1回 Guidance
Guidance
第2回 The genetic principle for generation of antibody diversity
Susumu Tonegawa won the Nobel prize in Physiology or Medicine 1987 for for his discovery of the genetic principle for generation of antibody diversity.
第3回 TOF-MS
Koichi Tanaka won the Nobel prize in Chemistry 2002 for the development of methods for identification and structure analyses of biological macromolecules.
第4回 Destinations of proteins
Günter Blobel won the Nobel prize in Physiology or Medicine 1999 for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell. James E. Rothman, Randy W. Shcekman, and Thomas C. Südhof won the Nobel prize in Physiology or Medicine 2013 for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.
第5回 Great studies by using flies
Christiane Nüsslein-Volhard won the Nobel prize in Physiology or Medicine 1995 for her discovery concerning the genetic control of early embryonic development
Jeffrey C. Hall, Michael rosbash, Michael W. Young won the Nobel prize in Physiology or Medicine 2017 for their discoveries of molecular mechanisms controlling the circadian rhythm.
第6回 Mechanism for Autophagy
Yoshinori Ohsumi won the Nobel Prize in Physiology or Medicine 2016 for his discoveries of mechanisms for autophagy.
第7回 Apoptosis & Ubiquitin
Aaron Ciechanover, Avram Hershko, and Irwin Rose won the Nobel prize in Chemistry 2004 for the discovery of ubiquitinmediated
protein degradation
Sydney Brenner, H. Robert Horvitz, and John E. Sulston won the Nobel prize in Physiology or Medicine 2002 for their
discoveries concerning genetic regulation of organ development and programmed cell death.
第8回 Great Drugs
Satoshi Omura and William C. Campbell won the Nobel prize in Phisiology or Medicine 2015 for their discoveries
concerning a novel therapy against infections caused by roundworm parasites. Youyou Tu also won the Nobel prize in
Phisiology or Medicine 2015 for her discoveries concerning a novel therapy against Malaria.
第9回 The mechanism of transcription in eukaryotes
Roger D. Kornberg won the Nobel prize in Chemistry 2006 for his studies of the molecular basis of eukaryotic transcription.
Andrew Z. Fire and Craig C. Mello won the Nobel prize in Physiology or Medicine 2006 for their discovery of RNA
interference - gene silencing by double-stranded RNA.
第10回 Stem cell technologies
Mario R. Capecchi, Sir Martin J. Evans, and Oliver Smithies won the Nobel prize in Physiology or Medicine 2007 for their
discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells. Shinya
Yamanaka and Sir John B. Gurdon won the Nobel prize in Physiology or Medicine 2012 for the discovery that mature cells
can be reprogrammed to become pluripotent.
第11回 Special lecture 1
According to the timely topics, I will invite some special speakers for this class.
第12回 Special lecture 2
According to the timely topics, I will invite some special speakers for this class.
第13回 Special lecture 3
According to the timely topics, I will invite some special speakers for this class.
第14回 Special lecture 4
According to the timely topics, I will invite some special speakers for this class.
第15回 Summary
The lecture #1-14 will be summarized in this time, and let's discuss what kind of research worthy of the Nobel prize.
15回目に相当するその他の授業計画
Some reports